Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Type I

Mediator

IgE antibodies

Onset

  • Less than 1h

  • Rarely 1-72h

Clinical Reaction

  • Anaphylaxis

  • Urticaria (hives)

  • Hypotension

  • Bronchospasm

  • Angioedema

  • Pruritus

  • Penicillins: ~0.01-0.05%

  • Cephalosporins: ~0.0001-0.1%

Management

  • May use a beta-lactam from a DIFFERENT class with different side chain.

  • Consider starting with test dose graded procedure.

  • Consider desensitization.

  • Consider alternative antibiotics.

Consult ID

Cross-Reactivity

Desensitization