Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Cefuroxime

C. diff Risk

Medium

Oral Bioavailability

Moderate

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Adult

750-1500mg IV q8h

500mg PO q12h

General Information

Common Usage

Common Usage

  •  Community acquired pneumonia with a macrolide

  •  Intraabdominal infection

  •  Epiglottitis

Adverse Effects

Adverse Effects

  •  Allergy (immediate & delayed)

  •  Positive Coombs

  •  Cytopenias

  •  GI upset

  •  Diarrhea

  •  Abnormal liver enzymes

Major Interactions

Major Interactions

May enhance anticoagulant effect of vitamin K antagonists
Probenecid may increase cefuroxime levels

Pharmacology

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor at usual doses

Lung penetration: Therapeutic

Urine penetration: Therapeutic