Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Amoxicillin-Clavulanate

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

CrCl Less Than 10 mL/min250-500 mg q24h

CrCl 10-24 mL/min250-500 mg BID

CrCl 25-49 mL/min500-875 mg BID

CrCl Greater Than 50 mL/min500-875 mg BID

Adult

875mg PO BID or 500mg PO TID of the amoxicillin component

General Information

Common Usage

Common Usage

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

Drug Monitoring

Drug Monitoring

For prolonged therapy, monitor liver enzymes and function.

Adverse Effects

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Note EBV related rash

  •  Cytopenias

  •  Diarrhea

  •  Hepatotoxicity due to clavulanate - usually mild, liver failure is rare.

Major Interactions

Major Interactions

Increased risk of rash with allopurinol

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic