Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

CrCl Less Than 30 mL/minNitrofurantoin should be avoided

CrCl Greater Than 30 mL/min100 mg PO BID

Adult

Cystitis
Macrobid 100 mg PO BID

General Information

Common Usage

Common Usage

Uncomplicated cystitis in females with normal renal function

Adverse Effects

Adverse Effects

Interstitial pneumonitis and fibrosis especially with prolonged use.

Peripheral neuropathy.

Major Interactions

Major Interactions

Antacids decrease absorption

Additional Information

Additional Information

Think of this drug as a urinary antiseptic.

Not recommended in males due to inadequate tissue penetration, especially with possible occult prostatitis.

Pharmacology

Pharmacology

Antimicrobial class: Nitrofuran

Pregnancy category: B (Contraindicated at term)

Average serum half life: 1 hour

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: Therapeutic