Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Norfloxacin

C. diff Risk

High

Oral Bioavailability

Moderate

Approximate Cost

Non-formulary

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Adult

400 mg PO BID

General Information

Unacceptable Uses

Non-Formulary

Non-formulary

Common Usage

Common Usage

Prophylaxis of spontaneous bacterial peritonitis.
Urinary tract infection
Prostatitis
Uncomplicated UTI.

Drug Monitoring

Drug Monitoring

Monitor QTc in patients with increased risk

Adverse Effects

Adverse Effects

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Increased liver enzymes

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis

  • Leukopenia, thrombocytopenia

Major Interactions

Major Interactions

Other QTc prolonging agents.

Divalent cations - Decreased absoprtion.

Methadone - Increased seizures.

Thyroid replacement - Decreases T.

Warfarin - Increased INR.

Pharmacology

Pharmacology

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Urine penetration: Therapeutic