Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Caspofungin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

70 mg IV once then 50 mg IV daily

Hepatic

Severe Impairment (Child-Pugh Class C):The manufacturer provides to dosing guideline. Not studied.

Moderate Impairment (Child-Pugh Class B):70 mg IV once then 35 mg IV daily

Mild Impairment (Child-Pugh Class A):No adjustment required

General Information

Common Usage

Common Usage

Therapy of suspected and confirmed invasive fungal infections

Adverse Effects

Adverse Effects

  •  Increased liver enzymes

  •  GI upset

Major Interactions

Major Interactions

Decreases levels of Tacrolimus
Cyclosporine may increase levels of Caspofungin
Rifampin may decrease Caspofungin concentrations

Pharmacology

Pharmacology

Antimicrobial class: Echinocandin

Pregnancy category: C

Average serum half life: 10 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor