Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

No adjustment required

Adult

1-2g IV q4-6h
Endocarditis: 2g IV q4h
250-500 mg IM q6h
250-500 mg PO QID

General Information

Common Usage

Common Usage

Treatment of MSSA infections

Adverse Effects

Adverse Effects

  • Allergy (immediate or delayed)

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Phlebitis at injection site in a peripheral vein

Major Interactions

Major Interactions

Can increase methotrexate levels.

Decrease mycophenolate levels.

Tetracyclines can diminish cloxacillin activity.

Pharmacology

Pharmacology

Antimicrobial class: Antistaphylococcal Penicillin

Pregnancy category: B

Average serum half life: 1 hr

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic