Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Cefepime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Non-Formulary

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

CrCl Less Than 11 mL/min500mg-1g IV q24h

CrCl 11-29 mL/min1-2g IV q24h

CrCl 30-50 mL/min2g IV q12-24h

CrCl Greater Than 60 mL/min2 g IV q8-12h

Adult

1-2g IV q8-12h

General Information

Unacceptable Uses

Non-Formulary

Cefepime is non-formulary at MSH.

Common Usage

Common Usage

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms.

Adverse Effects

Adverse Effects

  • Allergy (immediate & delayed)

  •  Positive Coombs

  •  Cytopenias

  •  Non-convulsive status epilepticus (resolves with discontinuation of cefepime)

  •  Elevated liver function tests

  •  Prolonged PT/PTT

  •  Infusion related reactions, including red man syndrome have been reported

  •  Headache

Pharmacology

Pharmacology

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic