Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Secondary Peritonitis

Antifungal Therapy

Empiric antifungal therapy is generally NOT indicated for GI perforation unless patient has one of the following risk factors:

  •  Esophageal perforation,

  •  Immunosuppression

  •  Prolonged antacid therapy

  • Prolonged antibiotic therapy

  •  Prolonged hospitalization

  •  Persistent GI leak

Initial Empiric Therapy

Fluconazole 400 mg IV/PO every 24 hr*

*Clinically stable patients without prior long-term azole therapy.