Sepsis

If the patient meets all 3 of the criteria listed below, the patient has severe sepsis:

1. Suspected infection

2. ≥ 2 SIRS Criteria:

• Temperature ≥ 38.3°C or < 36°C

• Heart rate > 90 bpm

• Respiratory rate > 20 or mechanical ventilation

• WBC > 12,000 or < 4,000 mm3

3. Exhibit one acute organ dysfunction

• Systolic BP < 90 mmHg

or MAP < 65 mmHg after 30 ml/kg fluid bolus
- Serum lactate ≥ 2 mmol/L

• Coagulopathy

• Creatinine level > 2 mg/dl or elevation > 0.5 mg/dl above baseline

• Urine output < 0.5 ml/kg/hr for 2 hours

• PLT count < 100,000

• Bilirubin > 2 mg/dl (34.2 mmol/L)

• Acute respiratory failure