May be nosocomial or community onset and diarrhea usually develops after taking antibiotics.
Can occur in outbreaks.
Recurrence is very common therefore previous history of C. difficile is a risk factor.
Antacids, especially proton-pump inhibitors, and chemotherapy also increase risk.
Wide range of symptoms possible.
Profuse, watery diarrhea
Pseudomembranous colitis or toxic megacolon.
Discontinue concomitatnt antibiotics whenever possible.
Probiotics may be helpful.
The lab will only accept liqued (diarrhea) stools, and only once in 7 days.
In refractory cases, stool transplants have been effective.
