Clostridium perfringens

Precautions

See 'Additional Information'
See 'Additional Information'

General Information

First Line Treatment

Penicillin + Clindamycin

Pathogen information

Anaerobic spore forming gram positive bacilli, box-car shaped.

Epidemiology

Environmental (soil, water) organism as well as human/animal digestive tract.

Associated with penetrating wounds with environmental exposure.

Associated syndromes

  •  Gas gangrene/Clostridial myonecrosis

  •  Necrotizing skin and soft tissue infection

  • Septic abortion

  • Intra-abdominal abscess

  • Fatal bacteremia with massive exotoxin-mediated hemolysis

  • Foodborne self-limited gastrointestinal illness

Additional Information

Surgical debridement of devitalized tissue crucial.

IVIG and hyperbaric oxygen may be considered but lack of rigorous studies to support routine use.