Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Oxacillin

C. diff Risk

NA

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

No specific dose adjustment provided by the manufacturer

Adult

1-2 g IV every 4-6 hr

Pediatric

General Information

Common Usage

Common Usage

Treatment of MSSA infections

Drug Monitoring

Drug Monitoring

Lab

  • Baseline and periodic CBC with differential

  • periodic urinalysis/CMP

Clinical

  • Hypersensitivity

  • Drug interactions (warfarin)

  • GI effects/diarrhea

Adverse Effects

Adverse Effects

  • Allergy

  • Phlebitis at injection site

  • C. difficile diarrhea

  • Abnormal liver enzymes

  • Cytonpenias

  • Interstitial nephritis

Major Interactions

Major Interactions
  • Warfarin decreased PT/INR

Pharmacology

Pharmacology

Antimicrobial class: Antistaphylococcal penicillin

Pregnancy category: B

Average serum half life: 0.9-1.8 hr

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic