Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Ceftolazone-Tazobactam

Restricted
Restricted

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Adult

May only be ordered by an Infectious Disease Physician

1.5 g IV every 8 hr

General Information

Acceptable Uses

Acceptable Uses

  • Reserved for multi-drug resistant (MDR) pseudomonas

  • Documented CRE infection

Unacceptable Uses

Unacceptable Uses

  • Emperic therpay

  • Management of non-multidrug resistant infections

Drug Monitoring

Drug Monitoring

Lab

  • periodic CBC and CMP

Clinical

  • Hypersensitivity reaction

  • GI effects, diarrhea

Adverse Effects

Adverse Effects

  • GI intolerance

  • Hypersensitivity reaction

  • Headache

Pharmacology

Pharmacology

Antimicrobial class: Cephalosporin combination

Pregnancy category: B

Average serum half life: Ceftolazone: 3 hr
Tazobactam: 1 hr

Route of Elimination: primarily urine