Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Ceftazidime-Avibactam

Restricted
Restricted

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Adult

May only be ordered by Infectious Disease Physician

2.5 g IV every 8 hr

General Information

Acceptable Uses

Acceptable Uses

  • Reserved for patients with little or no alternative treatment options

  • Management of documented CRE infection

Unacceptable Uses

Unacceptable Uses

  • Emperic therpay

  • Management of non-multidrug resistant infections

Common Usage

Common Usage

Patients with documented CRE infection

Drug Monitoring

Drug Monitoring

Lab

  • periodic CBC and CMP

Clinical

  • Hypersensitivity

  • Monitor for neurotoxicity

  • GI effects

Adverse Effects

Adverse Effects

  • Diarrhea, N/V

  • Pruritis

  • Hypersensitivity reaction

Pharmacology

Pharmacology

Antimicrobial class: Cephalosporin combination

Average serum half life: 2.76 hr

Route of Elimination: Primarily urine