Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Colistin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Adult

Consult Infectious Disease

2.5-5 mg/kg/day IV divided into 2-4 doses

General Information

Acceptable Uses

Acceptable Uses
  • Management of multi-drug resistant infections caused by Enterobactericiae, Acinetobacter, and Pseudomonas (on a case by case basis)

Unacceptable Uses

Unacceptable Uses

  • Mangement of infections due to non-multidrug resistant pathogens

  • Prophylaxis

Common Usage

Common Usage

Severe infections caused by multidrug-resistant gram-negative organisms when other antimicrobial options are limited.

Drug Monitoring

Drug Monitoring

Lab

  • periodic CBC and BMP

Clinical

  • Monitor for nephrotoxicity

  • monitor for neuromuscular blockade

Adverse Effects

Adverse Effects

  • Phlebitis at infusion site

  • Neurotoxicity

  • Nephrotoxicity in up to 20% of patients

  • Inhaled form: bronchospasm

Pharmacology

Pharmacology

Pregnancy category: C

Average serum half life: 2-3 hr

Route of Elimination: Primarily urine