Ceftaroline is a newer broad spectrum cephalosporin with a spectrum of activity similar to ceftriaxone, but with activity against MRSA.

Gram positive

• MSSA

• MRSA

• Streptococcus pneumoniae

Gram negative

• Haemophillus influenzae

• Escherichia coli

• Klebsiella pneumoniae

Anaerobes

• Limited activity against Bacteroides fragillis

No activity

• Pseudomonas

• Acinetobacter

• Extended spectrum beta-lactamase producers

• AmpC-derepressed Enterobaceriaceae