Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Rifampin

C. diff Risk

NA

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Should not be used as monotherapy

Tuberculosis
600 mg IV/PO every 24 hr

Endocarditis
300 mg IV/PO every 8 hr

Prosthetic joint/Osteomyelitis infections
450 mg IV/PO every 12 hr

General Information

Common Usage

Common Usage

Mycobacterial infections, Brucellosis, osteomyelitis, and prosthetic joint infections due to Staphyloccocus aureus (always use in combination with other agents).

Drug Monitoring

Drug Monitoring

Lab

  • Basline and periodic LFTs

Clinical

  • Multiple drug interactions

Adverse Effects

Adverse Effects

  • Nausea/vommiting, diarrhea

  • abnormal liver enzymes

  • rash (Steven-Johnson syndrome)

  • myopathy

Major Interactions

Major Interactions

Inducer of many CYP enzymes including 3A4, and 2C9. Review patients medications carefully.

Additional Information

Additional Information

  • Should never be used as monotherapy

  • May discolor bodily secretions (yellow-reddish). Caution in contact lens wearers.

Pharmacology

Pharmacology

Antimicrobial class: Antimycobacterial

Pregnancy category: C

Average serum half life: 3-4 hr

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Route of Elimination: Feces