Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Cefotaxime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

Reserved for Neonatal and Pediatrics

Pediatric

General Information

Common Usage

Common Usage

Empiric therapy for:

  •  Bacterial meningitis

  •  Pneumonia (in combination with a macrolide)

  •  Intra-abdominal infection including SBP

  •  Musculoskeletal i.e. septic arthritis

  •  Urinary tract infection

Drug Monitoring

Drug Monitoring

Lab

  • CBC

  • CMP

Clinical

  • Hypersensitivity

  • Diarrhea

Adverse Effects

Adverse Effects

  •  Rash

  •  Localized phlebitis at injection site

  •  Allergy

  •  Positive Coombs test

  •  Neutropenia

  •  Abnormalities in liver enzymes

  •  Diarrhea

  •  CDI

Additional Information

Additional Information

Prefer ceftriaxone for CNS infection in renal failure.

Pharmacology

Pharmacology

Antimicrobial class: 3rd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 1.5 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic