Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

1-2 g IV every 8 hr

Pediatric

General Information

Common Usage

Common Usage

Skin and soft tissue infection (e.g. cellulitis)

Surgical prophylaxis

Susceptible Staphylococcal, Streptococcal and gram negative infections

Drug Monitoring

Drug Monitoring

Lab

  • CBC, CMP

Clinical

  • Hypersensitivity

  • GI effects

Adverse Effects

Adverse Effects

  • Allergy (immediate or delayed).

  • Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Major Interactions

Major Interactions

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin.

Not recommended unless no other alternatives.

Pharmacology

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic