Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Penicillin VK

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

No dose adjustment provided in manufacturer's labeling. Use with caution, excretion is prolonged in renal impairment.

Adult

250-500 mg PO every 6-8 hr

General Information

Common Usage

Common Usage

Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (i.e. upper respiratory tract).

Prophylaxis after rheumatic fever.

Drug Monitoring

Drug Monitoring

Lab

  • Periodic CBC, SCr

Clinical

  •  Monitor for allergy

Adverse Effects

Adverse Effects

  • Allergy (anaphylaxis) and other rash

  • Cytopenias, Positive Coombs, Eosinophilia

  • Serum sickness

  • AIN

Major Interactions

Major Interactions

No significant interactions

Pharmacology

Pharmacology

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Lung penetration: Therapeutic

Urine penetration: Therapeutic