Low
Excellent
Requires Infectious Disease consultation for use OR completion of the Restricted Antimicrobial order form for approved indications
600 mg PO/IV every 12 hr
Note: No restriction on oral therpy when being used to prepare patient for discharge
Infection caused by Staphylococcus spp. resistant to beta-lactams AND a serious allergy to vancomycin (i.g. anaphylaxis, hives)
Infection caused by Staphylococcus spp. with a vancomycin MIC >2
Transition of therapy to facilitate discharge
Systematic infection with documented Enterococcus spp. resistant to vancomycin and ampicillin
Enterococci cystitis resistant to ampicillin, vancomycin, nitrofurantoin, fosfomycin, tetracycline (do not substitute for another tetracycline antibiotic)
Patients failing vancomycin therapy which is defined as clinical decompensation or failure after 7 days of therapy despite adequate source control and therapeutic levels of vancomycin
Convenience (patients with renal dysfunction)
Empiric therapy for suspected staphylococcal infection
VRE colonization of the stool, urine, respiratory tract, wounds, or drains
Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia.
Covers MRSA and VRE.
Lab
Clinical
Hypersensitivity
GI effects
Neuropathy
Visual changes/function with therapy ≥ 3 months
Serotonin syndrome
Rash
Elevated liver enzymes
Lactic acidosis
Myelosuppression (usually with >2weeks therapy) - reversible
SSRI and other serotonergics/MAOIs - Increased risk of serotonin syndrome.
Rifampin decreases linezolid levels.
Antimicrobial class: Oxazolidinone
Pregnancy category: C
Average serum half life: 5 hours
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
