Low
NA
Requires Infectious Disease consultation for use OR completion of the Restricted Antimicrobial order form for approved indications
100 mg IV every 24 hr
Positive blood or other sterile site culture (non-urinary and non-sputum) for Candida species until susceptibilities are available or demonstarting fluconazole resistance
Fungal infection empiric therapy, or treatment of patients with solid organ transplant
Fungal infection empiric therapy, or treatment of patients receiving cancer chemotherapy with concurrent neutropenia
Fungal infection prophylaxis or treatment in hematopoietic stem cell transplant patients
Short-term empiric therapy for febrile ICU patients despite antibiotic therapy with sepsis (>38 degree Celsius) AND at least one risk factor for candidemia (risk factors for candidemia have been identified but are of low predictive value when evaluated individually: receipt of parenteral nutrition, gastrointestinal tract surgery during current admission, Candida colonization of multiple body sites, multiple organ failure, esophageal perforation, central line)
Combination therapy for refractory mold infection (e.g. aspergillus)
First line therapy for Candida or aspergillosis infections in non-critically ill patients
Antimicrobial class: Echinocandin
Pregnancy category: C
Average serum half life: 15 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Poor
