High
Excellent
Fluoroquinolones should be avoided in pediatric patients whenever possible
Mild to moderate infections
10 mg/kg/dose PO every 12 hr (500 mg/dose max)
Severe infections
15-20 mg/kg/dose PO every 12 hr (750 mg/dose max)
10 mg/kg/dose IV every 8-12 hr (400 mg/dose max)
Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen and other sites
Clinical
Monitor QTc in patients with increased risk
Increased INR (warfarin)
Hypersensitivity
GI effects
tendonitis
QTc prolongation
Dysglycemia
Tendinopathy and rupture
GI upset
Rash
Retinal detachment
CNS toxicity including confusion, psychosis
Weakness exacerbation in myasthenia gravis
CYP1A2 inhibitor - Multiple interactions possible.
QTc prolongation - Increased risk with other agents that prolong QTc.
Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption
Cyclosporine - Increased levels of cyclosporine
Warfarin - Increased INR
Methadone - Lowered seizure threshold
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: 4 hours
Biliary penetration: Therapeutic
CSF penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic
