Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Ertapenem

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Adult

Restricted to Infectious Disease physicians OR or patients with documentation of one of BMH's approved criteria for use

1 gm IV every 24 hr

General Information

Acceptable Uses

Acceptable Uses

  • ESBL+ E.coli or Klebsiella pathogens

  • Transition of therapy to facilitate discharge to home or SNF - single dose use

Unacceptable Uses

Unacceptable Uses

  • Empiric therapy

  • Infections in which Psuedomonas or Acinetobacter are suspected

Common Usage

Common Usage
  • Targeted therapy of ESBL infections and other resistant gram negative infections.

Drug Monitoring

Drug Monitoring

Lab

  • periodic SCr and LFTs

Clinical

  • Hypersensitivity

  • GI effects

  • Seizures (rare)

Adverse Effects

Adverse Effects

  • Immediate and delayed-type allergy

  • GI disturbance

  • Cytopenias, eosinophilia, positive Coombs

  • Liver enzyme abnormalities

  • Seizure risk lower than other carbapenems

Pharmacology

Pharmacology

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 4 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic