Has the same spectrum of activity as Ampicillin plus organsims producing beta-lactamases such as MSSA, H. influenzae, E.coli, Klebsiella, Enterobacter, and anaerobes.

However, an increasing number of E.coli and Proteus species are now resistant.

Gram positive

• Streptococci

• Enterococci

• Listeria

Gram negative:

• Neisseria meningitidis

• Pasturella multocida

Anaerobes

• Actinomyces

• Non-difficile Clostridia

• Peptostreptococci