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Guidelines
Pathogens
Antimicrobials
Medium
NA
2 gm IV q8h (max 6 gm/day)
Skin and soft tissue infection (e.g. cellulitis).
Surgical prophylaxis.
Susceptible Staphylococcal, Streptococcal and gram negative infections.
Allergy and rash as for all beta-lactams.
Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.
Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin.
Not recommended unless no other alternatives.
Antimicrobial class: 1st Generation Cephalosporin
Pregnancy category: B
Average serum half life: 2 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Therapeutic