Spectrum: Local Antimicrobial Stewardship, for NYC Department of Health

Ciprofloxacin

C. diff Risk

High

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

PO: 500-750mg po q12h

IV: 400mg IV q8-12h

Renal

General Information

Common Usage

Common Usage

Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen and other sites.

Drug Monitoring

Drug Monitoring

Monitor QTc in patients with increased risk.

Adverse Effects

Adverse Effects

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis.

Major Interactions

Major Interactions

  • Other QTc prolonging agents

  • Divalent cations - Decreased absorption

  • NSAIDs - Increase seizure risk

  • Warfarin - Increased INR

Pharmacology

Pharmacology

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic