Spectrum: Local Antimicrobial Stewardship, for NYC Department of Health

Ceftriaxone

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Usual Dose 1-2 gm IV q24h

Bacterial meningitis 2 gm IV q12h

General Information

Common Usage

Common Usage

Empiric therapy of:

  • Bacterial meningitis

  • Nosocomial gram negative infections (except Pseudomonas)

  • Spontaneous bacterial peritonitis

  • Hospitalized community or nursing healthcare associated pneumonia in combination with a macrolide

Adverse Effects

Adverse Effects

  • Allergy and rash as for all beta-lactams

  • Cytopenias

  • Eosinophilia

  • Hepatic & renal laboratory abnormalities

  • Pseudocholelithiasis. Unclear clinical significance. Uncommonly symptomatic, but frequently by ultrasound gallbladder sludge.

Pharmacology

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic