Coagulase negative Staph CRBSI

Consider contamination in the setting of a single positive blood culture or line tip positivity without a positive blood culture

Repeat blood culture q24-48h until negative

If susceptible, treat with cloxacillin or cefazolin

With catheter removal, shorter duration appropriate with this organism (0 - 5 days), unless

patient has intravascular hardware (i.e. pacemaker, prosthetic valve), then longer duration required and must rule out endocarditis - discuss with Infectious Diseases

If catheter retention desired,

fever and bacteremia MUST resolve within 72h AND patient must not have intravascular hardware, signs of endocarditis or local signs of inflammation