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Antimicrobials
Diffuse peritonitis OR severe sepsis
Severe sepsis is defined by all three of:
SIRS criteria (Two of HR>90, tachypnea, Temp >38 or <36, WBC >12 or <4)
Suspected/confirmed infection
At least one new organ dysfunction (hypotension, elevated lactate, AKI, acute lung injury, DIC, neurologic or hepatic)
Antibiotic use >2d within 30d
Delayed (>24h) or inability to achieve source control
Admission to hospital for ≥5d OR immunocompromised
Community acquired infection
Early surgery (<24h) for gastric, duodenal or proximal jejunal perforation without cancer, or anti-acid therapy