FN - Risk Stratification

Hemodynamic instability, altered LOC, hypoxemia, new infiltrate on CXR, GI symptom, catheter tunnel site infection, OR cellulitis >5cm

Anticipated duration of neutropenia >7 days

Hematologic malignancy, especially AML or allo-HSCT

Previous fungal infection

Significant symptoms, i.e. dyspnea, pain

Oral mucositis with ulceration that affects eating (or worse)

Significant comorbidity, including uncontrolled COPD, renal failure with eGFR<30, hepatic dysfunction

Colonized/previous infection with a resistant organism