MSSA

Anti-staphylococcal penicillins (i.e. cloxacillin) and cephalosporins (i.e. cefazolin) are optimal agents for intravenous therapy of MSSA infections.

Variable susceptibility to:

•  TMP-SMX,

•  Clindamycin

•  Tetracyclines

MRSA

Susceptible to:

• Vancomycin

• Daptomycin

• Linezolid

Variably susceptible to:

• TMP-SMX

• Clindamycin

• Tetracyclines

By definition resistant to cloxacillin and cephalosporins.

Clindamycin/TMP-SX/Tetracycline are not reported for sterile site isolates and should not be used for bacteremia, CNS infection etc