Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Colistin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$24.98

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

Most commonly prescribed in terms of mg of Colistin base activity

Pharmacy consultation recommended to ensure appropriateness of dose

2.5-5 mg/kg/day IV divided into 2-4 doses

General Information

Acceptable Uses

Acceptable Uses

Management of multi-drug resistant infections caused by Enterobactericiae, Acinetobacter, and Pseudomonas (on a case by case basis)

Unacceptable Uses

Unacceptable Uses

  • Mangement of infections due to non-multidrug resistant pathogens

  • Prophylaxis

Common Usage

Common Usage

Severe infections caused by multidrug-resistant gram-negative organisms when other antimicrobial options are limited.

Drug Monitoring

Drug Monitoring

Clinical

  • Monitor for nephrotoxicity

  • monitor for neuromuscular blockade

Adverse Effects

Adverse Effects

  • Phlebitis at infusion site

  • Neurotoxicity

  • Nephrotoxicity in up to 20% of patients

  • Inhaled form: bronchospasm

Major Interactions

Major Interactions

Additive toxicity with other nephrotoxic drugs

Coverage

NLPDP Status

N/A

Additional Information

Additional Information

IV Administration
Dilute in 50-100 mL D5W or NS and administer over 30 min.

EH Prescribing Restrictions

  • None

  • Pharmacist review of therapy

Community IV Formulary (Metro Area)
YES

Pharmacology

Pharmacology

Pregnancy category: C

Average serum half life: 2-3 hr

Route of Elimination: Primarily urine