Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Caspofungin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$55.49

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

No dose adjustment required.

Poorly dialyzed, no supplemental doses required in hemodialysis.

Hepatic

Severe Impairment (Child-Pugh Class C)The manufacturer provides no dosing guideline. Not studied.

Moderate Impairment (Child-Pugh Class B)70 mg IV once then 35 mg IV daily

Mild Impairment (Child-Pugh Class A)No adjustment required

Adult

General Information

Common Usage

Common Usage

Therapy of suspected and confirmed invasive fungal infections

Adverse Effects

Adverse Effects

- Increased liver enzymes
- GI upset

Major Interactions

Major Interactions

  • Decreases levels of Tacrolimus

  • Cyclosporine may increase levels of Caspofungin

  • Rifampin may decrease Caspofungin concentrations

Coverage

NLPDP Status

N/A

Additional Information

Additional Information

IV Administration

  • NS only (incompatible with D5W).

  • Dilute in 250 mL NS, infuse over 60 min.

EH Prescribing Restrictions
None

Community IV Formulary (Metro Area)
YES

Pharmacology

Pharmacology

Antimicrobial class: Echinocandin

Pregnancy category: C

Average serum half life: 10 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor