Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Ampicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$11.64/day (IV)

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

1-2g IV q4-6h

2g IV q4h for meningitis or endocarditis

General Information

Common Usage

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria

Adverse Effects

Adverse Effects

Allergy and rash as for all beta-lactams.

EBV related rash (not allergy).

Rare: cytopenias, +ve Coombs.

Major Interactions

Major Interactions

Increased risk of rash with allopurinol.

Coverage

NLPDP Status

OPEN BENEFIT (PO)
No prescribing restrictions

Additional Information

Additional Information

IV Administration

  • Dilute in 50-100 mL NS and administer over 30 min.

  • Max concentration 30 mg/mL.

Prescribing Restrictions (IV)

  • None

  • Ampicillin PO orders are automatically substituted with Amoxicillin PO at Eastern Health

Community IV Formulary (St. John’s Metro)

  • NO

  • Limited Stability of IV ampicillin precludes use in Community IV program.

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic