Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Penicillin VK

C. diff Risk

Low

Oral Bioavailability

Moderate (40 to 70%)

Approximate Cost

$0.80/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

No dose reduction required

Adult

300 mg PO q6-8h

General Information

Common Usage

Common Usage

Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (i.e. upper respiratory tract).

Prophylaxis after rheumatic fever.

Drug Monitoring

Drug Monitoring

  •  Monitor for allergy.

  •  Periodic CBC, SCr

Adverse Effects

Adverse Effects

  • Allergy (anaphylaxis) and other rash

  • Cytopenias, Positive Coombs, Eosinophilia

  • Serum sickness

  • AIN

Major Interactions

Major Interactions

No significant interactions

Coverage

NLPDP Status

OPEN BENEFIT (PO)
No prescribing restrictions

Additional Information

Additional Information

EH prescribing restrictions:
None

Pharmacology

Pharmacology

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Lung penetration: Therapeutic

Urine penetration: Therapeutic