Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Aztreonam

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$207.90/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Adult

2g IV q8h for severe infections

General Information

Common Usage

Common Usage

Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent

Drug Monitoring

Drug Monitoring

Monitor liver enzymes

Adverse Effects

Adverse Effects

  •  Elevated liver enzymes

  •  Cytopenias

  •  Eosinophilia

  •  Phlebitis at injection site

  •  Rash/allergy

  •  CNS toxicity

Major Interactions

Major Interactions

No significant interactions.

Coverage

NLPDP Status

N/A

Additional Information

Additional Information

RESTRICTED - Available via Health Canada Special Access Program only

For special access drug availability contact:

IV Administration

  • Dilute in 50-100 mL D5W or NS and administer over 30-60 min.

  • Max concentration 20 mg/mL.

Community IV Formulary (Metro Area)
NO

Pharmacology

Pharmacology

Antimicrobial class: Monobactam

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic