Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Amoxicillin-Clavulanate

C. diff Risk

Medium

Oral Bioavailability

Good (70 to 90%)

Approximate Cost

$ 0.87/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

500mg PO TID of the amoxicillin component

Alternate Option

  • 875 mg PO BID

  • 875 mg tabs may be difficult to swallow

General Information

Common Usage

Common Usage

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

Drug Monitoring

Drug Monitoring

For prolonged therapy, monitor liver enzymes and function.

Adverse Effects

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Note EBV related rash

  •  Cytopenias

  •  Diarrhea

  •  Hepatotoxicity due to clavulinate - usually mild, liver failure is rare.

Major Interactions

Major Interactions

Increased risk of rash with allopurinol

Coverage

NLPDP Status

  • Open Benefit

  • No prescribing restrictions

Additional Information

Additional Information

EH Prescribing Restrictions
None

Tablets can be crushed and given via NG tube; Liquid also available

Bioavailability classification based on Amoxicillin component

Clavulanic acid bioavailability varies from 30-98%

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic