High
Good (70 to 90%)
$0.78 (PO)
$14.41 (IV)
Pneumonia including CAP, HAP, aspiration
Some intra-abdominal infections
CNS infections
QTc prolongation
Dysglycemia
Rash
Tendinopathy and rupture
GI upset
Weakness exacerbation in myasthenia gravis
CNS toxicity including confusion, psychosis
QTc prolongation - Increased risk with other agents that prolong QTc
Divalent cations including Ca, Mg - Decreased absorption
Warfarin - Increased INR
Rifampin - Decrease moxifloxacin levels
IV Administration
Premixed 400 mg bags; infuse over 60 min
Premixed bags are not compatible with pumps used in community IV program
EH Prescribing Restrictions
None (Pharmacist review of IV therapy)
NLPDP Status (PO)
Special Authorization required
Tablets can be crushed and given via NG route; No liquid formulation available
Bioavailability 85-90%
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: 12 hours
Biliary penetration: Therapeutic
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Poor
