Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Good (70 to 90%)

Approximate Cost

$1.68/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

Cystitis
Macrobid 100mg PO BID

General Information

Acceptable Uses

Acceptable Uses

Uncomplicated cystitis

Unacceptable Uses

Unacceptable Uses

Complicated UTI, bacteremia, pyelonephriris, urosepsis

The Beers Criteria recommends avoiding use in geriatric patients ≥65 years with a CrCl <30 mL/minute

Common Usage

Common Usage

Uncomplicated cystitis in females with normal renal function

Adverse Effects

Adverse Effects

Interstitial pneumonitis and fibrosis especially with prolonged use.

Peripheral neuropathy.

Major Interactions

Major Interactions

Antacids decrease absorption

Coverage

NLPDP Status

OPEN BENEFIT (PO)
No prescribing restrictions

Additional Information

Additional Information

For cystitis only. Do not use in bacteremia/pyelonephritis etc.

EH Prescribing Restrictions:
None

Most commonly used formulation is MACROBID 100 mg PO BID

If ordering NG, use nitrofurantoin tablets 50 mg QID

Pharmacology

Pharmacology

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: Therapeutic