Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Norfloxacin

C. diff Risk

High

Oral Bioavailability

Low (20 to 40%)

Approximate Cost

$1.20/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

400mg PO BID

General Information

Common Usage

Common Usage

Prophylaxis of spontaneous bacterial peritonitis.

Uncomplicated UTI.

Drug Monitoring

Drug Monitoring

Monitor QTc in patients with increased risk

Adverse Effects

Adverse Effects

  • QTc prolongation

  • Dysglycemia

  • Rash

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • CNS toxicity including confusion, psychosis

Major Interactions

Major Interactions

Other QTc prolonging agents.

Divalent cations - Decreased absoprtion.

Methadone - Increased seizures.

Warfarin - Increased INR.

Coverage

NLPDP Status

OPEN BENEFIT (PO)
No prescribing restrictions

Additional Information

Additional Information

EH prescribing restrictions:
None

Tablets can be crushed for NG administration; No liquid formulation available

Pharmacology

Pharmacology

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Urine penetration: Therapeutic