Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Doxycycline

C. diff Risk

Low

Oral Bioavailability

Excellent (90 to 100%)

Approximate Cost

$0.12 (PO)

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Hemodialysis, Peritoneal DialysisNo dose adjustment necessary.

No supplemental doses required after hemodialysis.

Adult

100mg PO BID

General Information

Common Usage

Common Usage

  • Skin and soft tissue infection

  • Community acquired pneumonia

  • Malaria prophylaxis

  • Methicillin resistant staphylococcus aureus (MRSA)infections

  • Sterile site S. aureus isolates such as blood should not be treated with doxycycline

Adverse Effects

Adverse Effects

  • GI upset and erosive esophagitis

  • Photosensitivity rash

  • Teeth staining

Major Interactions

Major Interactions

  • Divalent cations - decreased absorption

  • Increased digoxin levels

  • Increased INR with warfarin

  • Some anticonvulsants can decrease doxycycline levels

Coverage

NLPDP Status

OPEN BENEFIT (PO)
No prescribing restrictions

Additional Information

Additional Information

PO absorption of doxycycline is excellent. This route should be used in most cases.

EH Prescribing Restrictions

  • PO: None

  • IV doxycycline is available via Health Canada Special Access Program only.

  • For special access drug availability contact SAP program ((613) 941-2108 OR sapdrugs@hc-sc.gc.ca) or your Pharmacy department.

  • No liquid formulation available

  • Capsules can be opened and given via NG route

Pharmacology

Pharmacology

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic