Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Penicillin G

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$8.40/day
$92.22 IM

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

12-24 million units/day IV in 6 divided doses

Do not use short-acting IV formulation for single dose treatment of syphilis. This requires the long-acting 2.4 mu pen g benzathine formulation. May be single dose or multiple weekly doses depending on stage of syphilis.

ID consultation recommended

General Information

Common Usage

Common Usage

Therapy of Streptococcal and other documented susceptible infections.

Adverse Effects

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Seizures

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Serum sickness

Coverage

NLPDP Status

N/A

Additional Information

Additional Information

Pen G for IV infusion is not the same as the long acting benzathine IM formualtion. Used for syphilis; double check when ordering or dispensing

IV Administration
Dilute in 100 mL D5W or NS and administer over 30-60 min. (60 min for 4 or 5 mU doses)

EH Prescribing Restrictions
None

Community IV Formulary (Metro Area)
YES

Pharmacology

Pharmacology

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic