Low
NA
$550-650/day
Fungicidal therapy of yeast/fungus/mold infection.
Invasive candidiasis, aspergillosis, cryptococcosis.
Visceral/mucocutaneous Leishmaniasis.
Induction therapy for dimorphic fungii (cocci, blasto, histo).
Not for use in urinary tract infection.
Renal function
K
Mg
HCO3
Liver enzymes
CBC
Frequency depends on course, but daily reasonable during initiation
Same toxicities as conventional Amphotericin B but with less frequency.
Nephrotoxicity ++
Anemia
Phlebitis
Arachnoiditis
Urinary retention
Paresthesias
Infusion related symptoms
Fever
Rigors
N/V
Headache
Electrolyte abnormalities
HypoK and HypoMg
Loss of bicarb
See additional information
Main concern is concomitant nephrotoxins. Use should be minimized during amphotericin therapy.
Increased digoxin toxicity with hypokalemia.
Please specify formulation and patient weight when ordering
IV Administration
Abelcet (Lipid Complex)
D5W only (incompatible with NS);
Dilute to 1-2 mg/mL.
Administer over 2 hours.
Ambisome (Liposomal)
D5W only (incompatible with NS);
Dilute to 0.5-2 mg/mL.
Administer over 1-2 hours.
EH Prescribing Restrictions
Unrestricted - Pharmacist Review of Therapy
Community IV Formulary (Metro Area)
NO
Antimicrobial class: Antifungal. Polyene. Lipid formulations designed to minimize toxicity.
Average serum half life: 150 hours
Biliary penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Poor
