Low
Excellent
Urinary tract infections, skin and soft tissue infections, pulmonary infections, bone and joint infections, meningitis
Susceptible MRSA infections, Stenotrophomonas infections, Pneumocystis jirovecii pneumonia (treatment or prophylaxis), Nocardia infections
Follow creatinine, potassium, BUN in patients at increased risk renal failure or hyperkalemia
CBC
Stevens Johnson syndrome/toxic epidermal necrolysis, other rashes, gastrointestinal upset common, bone marrow suppression, hyperkalemia, renal failure, hepatitis, aseptic meningitis
ACEi - increased serum potassium level
Increases amantadine levels
Decreases cyclosporine
Methotrexate- marrow suppression
Increases phenytoin
Increases rifampin
Increases INR with warfarin
High dose therapy required for treatment of Pneumocystis pneumonia and Stenotrophomonas maltophilia infections
Antimicrobial class: Sulfonamide - Antifolate
Pregnancy category: C
Average serum half life: 10.0
Biliary penetration: Moderate
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
