Spectrum: Local Antimicrobial Stewardship, for Providence Health Care

Penicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

Penicillin G: 12-24 million units/day IV in 6 divided doses

Penicillin VK: 300-600mg PO BID-QID

General Information

Common Usage

Common Usage

Pencillin G: Therapy of Streptococcal and other documented susceptible infections, syphilis

Penicillin VK: Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (i.e. upper respiratory tract), Prophylaxis after rheumatic fever

Drug Monitoring

Drug Monitoring

Penicllin VK: Monitor for allergy. Periodic CBC, SCr

Adverse Effects

Adverse Effects

Penicillin G: Allergy/rash (immediate or delayed), seizures, cytopenias, eosinophilia, interstitial nephritis, abnormal liver enzymes, serum sickness

Penicillin VK: Allergy (anaphylaxis) and other rash, Cytopenias, Positive Coombs, Eosinophilia, Serum sickness, AIN

Major Interactions

Major Interactions

No significant

Pharmacology

Pharmacology

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic