Spectrum: Local Antimicrobial Stewardship, for Providence Health Care

Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

Cystitis: Macrobid 100mg PO BID

General Information

Common Usage

Common Usage

Uncomplicated cystitis with CrCl >40ml/min

Adverse Effects

Adverse Effects

Interstitial pneumonitis and fibrosis especially with prolonged use

Peripheral neuropathy

Major Interactions

Major Interactions

Antacids decrease absorption

Additional Information

Additional Information

Cannot be used for treatment of pyelonephritis

Pharmacology

Pharmacology

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: Therapeutic