Spectrum: Local Antimicrobial Stewardship, for Providence Health Care

Fosfomycin

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Dose post-hemodialysis

Adult

Female, uncomplicated cystitits: 3g PO once

Complicated or male cystitits: 3g PO q2-3days x 3 doses

General Information

Common Usage

Common Usage

Cystitis, especially involving ESBL producing organisms

Adverse Effects

Adverse Effects

  • GI upset, especially diarrhea

  •  Headache

Major Interactions

Major Interactions

No significant

Additional Information

Additional Information

Cannot be used for treatment of pyelonephritis.
At PHC, susceptibility testing will only be performed on E coli urine isolates. If fosfomyicn susceptibility is not released, call microbiology lab for more information.
IV formulation not available at this time.

Pharmacology

Pharmacology

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B

Average serum half life: 6.0

Urine penetration: Therapeutic