Low
Excellent
Skin and soft tissue infection, Methicillin resistant staphylococcus aureus infections, community acquired pneumonia, Malaria prophylaxis, Zoonoses
Divalent cations - decreased absorption
Some anticonvulsants can decrease doxycycline levels
Increased digoxin levels
Increased INR with warfarin
Di- & Trivalent cations including Al, Ca, Fe, Mg (anatacids, dairy products, iron supplements, some enteral feeds) - decreased absorption
May exacerbate muscle weakness in persons with myasthenia gravis. Contraindicated.
Antimicrobial class: Tetracycline
Pregnancy category: D
Average serum half life: 18.0
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Therapeutic
